In Vivo Anti-Inflammatory and in Vitro Antioxidant Activities of Toona Ciliata Leaves Native to Bangladesh

The study was performed to assess the anti-inflammatory, antioxidant activities and identify the polyphenols of Toona ciliata grown in Bangladesh. Anti-inflammatory activity was examined by the methods of carrageenan and histamine-induced paw edema. At the dose of 400 mg/kg, effective anti-inflammatory activity (P<0.01) was observed in rats for both the test models of carrageenan and histamine-induced paw edema, compared to indomethacin. In ABTS scavenging assay, IC50 value was found significant (5.50μg/ml) compared to ascorbic acid (12.01μg/ml). The maximum absorbance of reducing power was obtained 0.4939 at 250μg/ml relative to ascorbic acid (1.1115μg/ml). Total antioxidant capacity, total phenolic and flavonoid content were found to be 357.1 mg/g ascorbic acid, 239.2 mg/g gallic acid, and 98.36 mg/g quercetin equivalent, respectively. InVivoAntiInflammatoryandinVitroAntioxidantActivitiesofToonaCiliataLeavesNativetoBangladesh Strictly as per the compliance and regulations of: © 2014. Hemayet Hossain, Proity Nayeeb Akbar, Shaikh Emdadur Rahman, Tanzir Ahmed Khan, Md. Mahfuzur Rahman & Ismet Ara Jahan. This is a research/review paper, distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Khulna University, Bangladesh